Isolation of ubiquinone-11 and ubiquinone-12 from green peppers

Specific interaction between protein and ubiquinone in succinate-ubiquinone reductase.

The lack of ubiquinone in the isolated succinate-ubiquinone reductase (Complex II) and in some preparations of ubiquinone-binding protein (QPs) has caused some concern about the nature of interaction between ubiquinone and QPs. When a low concentration of radioactively labeled ubiquinone derivative in dilute detergent solution was incubated with delipidated or intact succinate-ubiquinone reduct...

Subsystem: Ubiquinone Biosynthesis

Quinones are widely distributed in nature. They are best known as lipid-soluble components of membrane-bound electrontransport chains, but in animal cells ubiquinone is found not only in the inner mitochondrial membrane but also in the endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, and in the plasma membrane. This distribution suggests that ubiquinones may be involved in a numb...

Ubiquinone Reductase from Bovine Heart Mitochondria

Metabolism, ubiquinone synthesis, and longevity.

Until recently, the mechanisms that control the aging process were thought to be immensely complex and nearly impossible to dissect at the molecular level. However, genetic analysis, primarily in model organisms such as yeast, worms, and flies, is dramatically changing this view. It seems that at least three distinct genetic networks control the aging process. These networks include the insulin...

Interaction and identification of ubiquinone-binding proteins in ubiquinol-cytochrome c reductase by azido-ubiquinone derivatives.

Various azido-ubiquinone derivatives were synthesized and characterized. 3-Azido-2-methyl-5-methoxy-6-(3,7-dimethyloctyl)-1,4-benzoquinone was found to be suitable for the study of specific interaction between ubiquinone (Q) and protein. It was synthesized with high specific radioactivity and used to identify the Q-binding proteins in purified ubiquinol-cytochrome c reductase. This azido-Q deri...